How long does it take to clone a 500GB drive?

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I'm thinking of installing TrueCrypt on my C: drive.  However, that
means my normal backup program will no longer work due to the
encrypted drive.  The answer I read is to clone the encrypted C: onto
a second drive.  This would seem to be an enormous pain if one
regularly installs/uninstalls programs.  I say that because I have the
idea that a sector by sector cloning must take a heck of a long time.

Has anyone any experience do this with their TrueCrypt installation?

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