Pros/Cons of submitting 1 large domaon or 4/5 subdomains?

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I have a large site that operates in several different market niches.
What are the pluses/minuses of submitting this as one large site
(giving a broader but diffuse message) or splitting it into the niches
using sub domains (more focuses).

Would a) DMOZ and b ) google et all have any "preference" or penalty
for either approach?

It seems more logical to me to split it........but getting traffic
determines the choice ;-)


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